Endocrine Abstracts

Introduction: Chronic heart failure (cHF) is an often and unrecognized cause of mortality among people with type 2 diabetes (T2D), more often in elderly. Assessment of cHF comprises of a combination of clinical symptoms, echocardiography and a biomarker N-terminal pro b-type natriuretic peptide. It is underestimated and not treated timely. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are treatment of choice for subjects with T2D and cHF, frequently not initiated in elderl...

Introduction: Monotherapy failure in diabetes mellitus type 2 occurs early in the course of disease. Evaluation of the primary pathogenetic mechanism is of primary importance in choosing the optimal combination therapy.Objectives: To investigate influence of meal stimulated C-peptide levels and HOMA B, as markers of residual insulin secretion on the efficasy of adding metformin to sulphonylurea therapy in subjects with metabolic syndrome, type 2 diabetes...

Introduction: The average age for physiological menopause is 50 years. Menopause before the age of 40 is usually defined as premature ovarian failure (POF). POF in adolescents is an extremely rare event and its occurrence raises important questions about the cause-and-effect relationship, which may signal genetic and systemic disorders.Design Case report: The 29-year-old first reported to an endocrinologist for secondary amenorrhea. The anamnesis reveale...

Introduction: Osteoporosis is a metabolic disease characterised by reduction of the bone mass density and deterioration of architecture of the bone and its strength. Continuous process of modeling and remodeling of bones is regulated by action of numerous circulating hormones. Fracture risk makes osteoporosis clinically important disease.Goal of this study was to examine thyroid dysbalance, parathormone secretion disorder as risk factors for osteoporosis...

Osteoporosis is a chronic noninfectious disease, which changes the structure and mineral density of bones, causing fractures after small trauma, deformities and disability. Every minute two breakages happen, due to osteoporosis. Thyroid gland disfunction could disturb the bone remodelling process.The aim of this study is to check the bone quality in females suffering from thyroid diseases. This prospective study included 164 women of the average age of 7...

The aim of this study was to investigate the contribution of thyroid and parathyroid glands dysphunction to the arterial hypertension ethiology in elderly patients suffering from hronic renal failure.In 34 patients, average age of 67 years (range: 65–68), with glomerular filtration rate (GFR, 99mTcDTPA) <60 ml/min, as well as the creatinine clearence (Cockcroft) values between 60 and 30 ml/min, thyroid gland function was analys...

Introduction: Ectopic Cushing’s syndrome caused by ectopic ACTH secretion are under-diagnosed.Case report: A 50 years old male patient is hospitalized for severe hypokalaemia and diabetes. Last 6 months he had a history of chest pain, prolonged cough, general weakness, difficulties climbing stairs, confusion, loss of consciousness. Previously, he was hospitalized in psychiatric hospital for psychotic alterations, in cardiology for high blood pressur...

Introduction: Low concentration of serum 25-hydroxyvitamin D (25-OHvitD) have been associated with low bone loss and risk of falls in postmenopausal women. Moderate obesity is not a risk factor for osteoporosis.Aim: The aim of this study was to investigate how vitamin D concentration correlates with muscle strength and bone density in moderately obese postmenopausal women.Methods: We include 33 postmenopausal women, between 50 and ...

Objective: Our goal was to investigate the effects of glucose levels from 75-g oral glucose tolerance test (OGTT) on large for gestational age (LGA) newborns in women with gestational diabetes mellitus (GDM).Material and methods: A prospective study was undertaken in Outpatient Department of Clinics for Endocrinology, Diabetes and Metabolic Disorders. One hundred and eighteen pregnant women were prospectively screened for GDM between 24 and 28 weeks of p...

Many studies show insufficient and inadequate vitamin D and calcium levels in postmenopausal women with osteoporosis, thus emphasising the need for supplementation therapy.Aim of the study: To determine vitamin D (25(OH)D) and ionised calcium levels in women treated for postmenopausal osteoporosis at our Clinic in the course of year 2009.Materials and methods: We prospectively followed up 116 women at the age of 59.38±5.55 (mi...